Idiopathic Pulmonary Fibrosis

Pulmonary fibrosis is a sever progressive pathological condition in many respiratory diseases. Idiopathic pulmonary fibrosis (IPF) is the most common with high morbidity and mortality. There is currently no cure and the two most commonly used drugs for treatment simply reduce progression but do not result in regression.  Axis Bio offer the bleomycin-induced lung fibrosis model in both mice and rats to study efficacy in both acute or chronic disease.

 

Non-induced

Non induced

Bleomycin-induced Vehicle

Bleomycin-induced Vehicle

Bleomycin-induced Pirfenidrone 100mg/kg QD

Bleomycin-induced

Pirfenidrone 100mg/kg QD

 

 

Idiopathic Pulmonary Fibrosis study

Non-Induced vs Bleo-induced vehicle ## p=0.0031

Bleo-induced vehicle vs Bleo-induced Pirfenidone * p=0.0377

 

 

 

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