Inflammation is a complex biological response to pathogens or irritants and is characterised by redness, swelling, heat and pain. Preclinical models have been developed to mimic both acute and chronic inflammatory disease; Axis Bio offers a range of models to cover each disease state. In addition to testing compounds in well-characterised, validated models, Axis Bio also offers clients the opportunity to develop models tailored to their specific needs.

During your study we will measure physiological outcomes associated with that disease, however we can also offer added value to your study by measuring relevant biomarkers, backed up by histopathology.

General Inflammation

A range of general models are available to screen anti-inflammatory compounds:

  • Paw edema model (rat)
  • Ear edema model (mouse)
  • Vascular permeability model
  • Cotton pellet granuloma model
  • Air pouch model

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Rheumatoid Arthritic

Both collagen and adjuvant induced models are available:

  • CIA model in mice and rats
  • AIA model in rats

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Inflammatory Bowel Disease

Models of IBD to mimic Ulcerative Colitis are available:

  • Dextran Sulphate induced Colitis (Acute/mouse)
  • Dextran Sulphate induced Colitis (Chronic/mouse)
  • TNBS-induced Colitis (Rat) 

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Sepsis

Sepsis is a serious medical condition characterised by dysregulated systemic inflammatory responses followed by immuno-suppression. 

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Psoriasis

Psoriasis is one of the most common immune-mediated chronic inflammatory skin disorders involved in the dysregulated interplay between immune cells and keratinocytes.

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Fibrosis

Fibrosis is the formation of excess connective tissue in an organ. 

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