The tumour microenvironment is a specialised niche that allows tumour cells to evade the immune system.  These conditions are very difficult to re-create in vitro however Axis Bio can offer s suite of functional assays for testing immuno-oncology agents.

General Info

To investigate the ability of a compound to activate the immune system, Axis Bio can offer the following assays:

  • Proliferation Assay
  • Migration Assay
  • Activation Assay
  • Modulation of differentiation and cytokine profile
  • Immune cell-mediated cancer cell killing
  • Exhaustion Assays

T-Cell Exhaustion Assay

Axis Bio is currently validating a T-cell exhaustion assay using cells isolated from tumour tissue.  This ex vivo assay will be available to test the ability of your compound to rescue exhausted tumour-associated T-cells in Q3 2019.

T-Cell Killing Assay

Axis Bio offers an in vitro T cell killing assay to evaluate the ability of your compound to modulate the immune response of effector cell subsets.

Immune cell-mediated killing of CT26 tumour cells.

 

To learn more about our services please visit our resources page or contact us.