The tumour microenvironment is a specialised niche that allows tumour cells to evade the immune system. These conditions are very difficult to re-create in vitro however Axis Bio can offer s suite of functional assays for testing immuno-oncology agents.
To investigate the ability of a compound to activate the immune system, Axis Bio can offer the following assays:
Axis Bio is currently validating a T-cell exhaustion assay using cells isolated from tumour tissue. This ex vivo assay will be available to test the ability of your compound to rescue exhausted tumour-associated T-cells in Q3 2019.
Axis Bio offers an in vitro T cell killing assay to evaluate the ability of your compound to modulate the immune response of effector cell subsets.
Immune cell-mediated killing of CT26 tumour cells.