As global incidences of respiratory disorders increase, the drive to develop and make available innovative therapeutic options is also increasing. To achieve this aim, and provide our clients with relevant, robust in vivo efficacy models, Axis Bio has validated the models shown in the table below. We offer intranasal and intratracheal routes of administration (or use of a nebuliser).

Type of analysis

The type of analysis performed varies from model to model, but we can offer the following:

  • Histology
  • ELISA for proinflammatory cytokines
  • BALF analysis
  • Respiratory Rate
  • Tidal Volume
  • Expiration Time
  • Respiratory Flow

Idiopathic Pulmonary Fibrosis

Axis Bio performs the bleomycin induced pulmonary fibrosis model and offers design flexibility to ensure alignment with our clients’ requirements. We run an acute, ‘target engagement’ model through to a more in depth, longer duration study.

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Other Respiratory Models

Acute lung damage
Axis Bio offers the HCl induced model.


  • Emphysema
  • Porcine pancreatic elastase induced model
  • Asthma

Axis Bio has a range of induction options:

  • Ovalbumin (OVA)-Induced
  • House dust mite induced
  • Cockroach allergen induced
  • Alternaria alternata-induced

To learn more about our services please visit our resources page or contact us.