Cell Line Derived Models

To measure the efficacy of your novel agent, Axis Bio has a range of validated tumour cell lines which can be implanted into immune-compromised mice or rats. All our in vivo xenograft models have been validated against standard-of-care agents.

Cancer Type

Cell lines

Validated growth curves available

Bladder

RT112

Brain

U87-MG, U251

Breast

MDA-MB-231, MDA-MB-468, MCF-7, T47D, ZR-75-1

Bone

Saos-2, U-2 OS

Colorectal

SW48, HT29, HT115, HCT116, SW620, LoVo, COLO 205

Hepatic

Hep3B, HepG2

Leukaemia

HL-60, MOLT-4, Jurkat, HSB-2

Lymphoma

Daudi, MC-37, GA-10

Melanoma

A2058, A375

Myeloma

MM.1S, RPMI8226, OPN-2

NSCLC

A427, A549

Ovarian

SK-OV-3, OVCAR3

Pancreatic

PANC-1, BxPC3, MIA PaCa-2, AsPC-1, PSN-1, HPAF-II, HPAC

Prostate

LNCaP, DU145, PC3, 22rv1, VCaP

Renal

A498, 786-0, ACHN

 

Our cell line collection is continually expanding. If a cell line of interest is not listed please contact us as it may be currently undergoing validation.

 

Orthotopic implantation/ Metastasis

Axis Bio has developed a proprietary collection of luciferase-expressing cell lines (including breast, glioma and pancreas) which can be utilised for orthotopic implantation and assessing metastatic spread using the IVIS imaging system. If we do not have a luciferase-expressing version of your cell line, we have the capability to generate and characterise these.

 

Contact us today for more details on these cell lines and expert advice on experimental models utilising them.