Axis Bio Services

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Pharmacokinetic Studies

Together with our commercial partner XenoGesis we can offer non-GLP LC-MS/MS quantitative bioanalysis with PK parameter determination of your novel therapy. Key PK parameters that can be reported include AUC, T½, CL, F, Cmax, tmax and PK profiles.

We can offer PK analysis on both mice and rats; details of typical studies can be found below. Please note that our standard service uses serial sampling of Sprague Dawley (rats) or CD-1 (mice) – parallel sampling and other strains are available on request. Please note that additional time points and cassette dosing are also available at additional cost.

Packages start from £3000. This package provides PK analysis of compound in mice or rats via iv and po with sampling over 8 time points, bioanalysis is included.

Typical rat study design:

Number of animals per group 3
Numbers of groups 2
Total number of animals 6
Dosing routes Any 2 from po,iv,im,ip,sc - others also available
Blood sampling Serial
Time points

po - 0, 5, 15, 30 minutes, 1, 2, 4 and 8 hours

iv - 3, 7, 15, 30 minutes, 1, 2, 4 and 8 hours

Study read-outs AUC, t1/2, CL, F, Cmax, tmax, PK profiles

 

Typical mouse study design:

Number of animals per group 9
Numbers of groups 2
Total number of animals 18
Dosing routes Any 2 from po,iv,im,ip,sc - others also available
Blood sampling Serial
Time points

po - 0, 5, 15, 30 minutes, 1, 2, 4 and 8 hours

iv - 3, 7, 15, 30 minutes, 1, 2, 4 and 8 hours

Study read-outs AUC, t1/2, CL, F, Cmax, tmax, PK profiles